Porcupines are only occasionally eaten in western culture, but are very popular in Southeast Asia, particularly Vietnam, where the prominent use of them as a food source has contributed to significant declines in their populations.
More commonly, their quills and guardhairs are used for traditional decorative clothing. For example, their guardhairs are used in the creation of the Native American "porky roach" headdress. The main quills may be dyed, and then applied in combination with thread to embellish leather accessories such as knife sheaths and leather bags. Lakota women would harvest the quills for quillwork by throwing a blanket over a porcupine and retrieving the quills it left stuck in the blanket.
Porcupine quills have recently inspired a new type of hypodermic needle. Thanks to backward-facing barbs on the quills, when used as needles, they are particularly good at two things - penetrating the skin and remaining in place.