Original Hybrid:
White Oak Stake: The only other physical weapon that can permanently kill an Original hybrid, It comes from an Ancient White Oak tree (no more in existence)Invitation: In order to enter any house owned by humans, Original hybrids have to be invited by that person. Once invited an Original hybrid cannot be uninvited. If a vampire lives in a house, a Original hybrid can enter freely and if an Original hybrid is in a house without being invited in it will become disoriented and will begin to suffocate.
Magic: As a supernatural entity a Original hybrid can be harmed or killed by a witch/warlock that can channel enough power. However, considering an Original hybrid's level of power this would likely be very difficult to achieve.
Dessication: A lack of blood will immobilize a Original hybrid.
Original Vampires:
White Oak Stake: (no more in existence)
Dessication: Being completely drained of blood or the heart stopping will cause an Original vampire to desiccate like any other vampire, losing most of it's strength and any ability to move.
Magic:It is said that a witch with enough power can kill/dangerously affect a being as powerful as an Original Vampire, but would likely kill the witch unless the Original vampire was in a weakened state.
Invitation: In order to enter any house owned by humans, they need to be invited in by a person that officially lives there or the person of entitlement. Once invited, the invitation cannot be revoked.
Sunlight: Sunlight will burn an Original vampire, but cannot kill them. All members of the Original Family possess lapis lazuli rings to combat this.
Werewolf bite: While a werewolf bite can't kill Original vampires, it weakens them and causes hallucinations. The effects are temporary and only lasts for a few hours.
White Oak Ash Daggers: A group of enchanted silver daggers dipped in the ash of the white oak tree will neutralize an Original vampire when stabbed through the heart.