A nuclear explosion wipes out a small town in Indiana, which either kills, or rewrites the cells of anyone caught in it's range. Some people weren't able to handle it's affects, others have been changed. Everyone who survived was given a supernatural ability. Hallie Osborn was affected by the explosion, and was one of the few people her age who survived, and is taken into a hospital of sorts for people like her. Finn doesn't remember anything outside of the hospital, the first thing he could remember was the chemical tank. He's not sure why he's put in there so often, but isn't allowed to ask many questions. He's eventually introduced to the rest of the gifted, he explains to Hallie his time in isolation, not understanding how important he's become. The doctors and therapists are keeping many things from the gifted, and with the help of Finn, Hallie's going to figure out what.

Jay Parker has escaped from his abusive family, and falls into view of Theo Novak, his former classmate. Theo allows him to stay in his basement, so he can stay hidden from his parents and the police. He can't wait to get Jay out of the house, in fear of his parents finding out, and getting both himself, and the other into serious trouble. But after Jay's been in the house for a while, he finds that Jay is the easiest person to talk to, and they're always caught up in a conversation whenever they can, which eventually leads Theo to have feelings he never thought he could have.

The Corona Virus is a thousand times more dangerous than anyone would have thought. Within 24 hours, whoever is affected will be dead, killed from the inside out. Earth is a ghost town, and staying put in a small house won't do any good. Jenny decides to take matters into her own hands and leave her town for good, hoping to find someone who's at least alive. Lucky for her, she finds Jasper, a cocky, but respectful guy who seems to know just about everything about how to survive the end of the world. He gives her a place to stay by introducing her to Asher, and many others at a hidden facility in the woods. Living there seems great at first, free food, a warm place to sleep, and social interaction. But the virus is nothing compared to the sinister events that unfold inside the camp, and seemingly in Asher's mind.