After Neo Cortex, Dr. N. Tropy and Uka Uka were last stranded on a distant planet. After decades of fruitless attempts, the trio finally make their escape, ripping an Evil-Scientist-sized hole in the fabric of space-time in the process (with help from Bertram). Now all that stands between them and total dominion over the multiverse are two fuzzy marsupials from N. Sanity Island, along with an intellectual baby and talking dog (Crash Bandicoot 4: It's About Time belongs to Activision, Family Guy belongs to Fox).

Mario and Luigi encounter a strange portal taking them on an inter-dimensional adventure with an alternate version of Tawna (Crash Bandicoot 4: It's About Time belongs to Activision, Super Mario belongs to Nintendo).

Bender wakes up at the Mosquito Marsh (a few days before Bertram finds Dr Cortex and N Tropy) and unexpectedly goes on an inter-dimensional adventure with Dingodile (Futurama belongs to Fox, Crash Bandicoot 4 It's About Time belongs to Activision).

A Bertram from a universe where he was reborn, travels the multiverse to team up with Dr Neo Cortex and Dr Nefarious Tropy to destroy Crash, Coco, Stewie, and Brian (Family Guy belongs to Fox, Crash Bandicoot 4 It's About Time belongs to Activision).