In a heart-wrenching journey of resilience and hope, "One Out of Four" follows the lives of two siblings, once part of a happy family shattered by a tragic loss. When their mother is brutally taken from them, the young boy and girl must navigate the unbearable pain of witnessing her death. As their father succumbs to grief and abandons them, they find themselves thrust into the unfamiliar world of foster care. Struggling to keep their family tragedy hidden, they endure the challenges of their new environment. However, their lives take a turn for the worse when the weight of grief becomes too much for the older brother to bear. Left in a coma after a suicide attempt, the sister refuses to leave his side, hoping for a miraculous recovery.

The high school year has begun for fifteen-year-old Lisa Hale. She experiences bullying and false accusations. She did not feel the need to inform her mother about her school drama. She eventually falls in love with a boy, but the feelings don't end there. Throughout her entire life, she has wondered where her father has gone. She suspects that Pamela, her mother, is hiding her father from her for a personal reason. Lisa recognizes that people aren't worth holding onto and makes an effort to be on her own. However, things quickly get worse. In her relationship with Lisa's father, Pamela, has endured a lot. After giving birth to Lisa, she did everything in her power to raise her as a single mother, but eventually things changed by one voice mail that was never meant to be heard by Lisa.