Shuichi and Kokichi grew up together in the same town, they were actually best friends. Until one day when the detective leave Japan for America. Years later, they meet again, only Shuichi is in desperate need for help.

16 students have been trapped inside of a school where they are forced to participate inside of a killing game. Our protagonist Shuichi Saihara has to deal with all of the chaos going on. He has already lost his best friend Kaede Akamastu, he doesn't want to lose anyone else. But, there is one boy making it a bit difficult to do so. Kokichi Ouma. Shuichi tries to ignore him to the best of his abilities but Kokichi oddly lures Shuichi in with his crazy antics. Kokichi is fond with the fact of Shuichi as well but hides it with teasing. They are both oddly tempted to know each other more and more. It's almost like destiny is pulling them together.