When a shipment of advanced medicines that was supposed to be sent to the M.B.I hospital ends up at the Hiyamakai hospital instead the nurses of the facility accidentally mix up Chiho's medicine with the New shipments that was supposed to be for Sekirei, the M.B.I medicine that they gave her started to mix with her deadly Virus that was slowly killing her causing a horrifying mutation to accrue in her body making her able to fight on the likes of Sekirei.

Sequel to Chiho's Mutation the evil avian looking aliens that are the Sekirians plan on invading the Earth after their experiments known as the Sekirei failed in doing so, that the Sekirei were created too wipe out all life on a single planet so the Sekirians Could conquer which pleases their eldritch master that hides In the fabrics of reality, the invasion takes place 16 years in the future from 2032.

Two years after the Sekirian invasion fails in capturing and bringing The Sekirei back to it, Tetaloth takes matters into it's own hands bringing forth the most vilest and dangerous beings throughout the cosmos to kill off the Sekirei, And if that plan fails than he is going to invade the Planet Earth himself to make the Alien Sekirei extinct forever.