When Earth enters an apocalyptic state due to the disease 'Zergraxis Fever' that causes the subject to develop a sixth sense, the system fails, the lights go off, and never come back on. The Risen have different breeds, from Jockeys to Whalers. Humans are Hybrids, the immune survive, but being immune is the least of your problems, and Inigo knows that all to well as he awakes in a forest, surrounded by the brain dead risen.

Ariebelle Bo, otherwise known as Annie, is innocently walking home from work when she is attacked by a gang. Lucky for her, she is saved by the famed Dynamic Duo. Before long, a romance starts to bud between her and Robin, making her a target for nearly every villain in Gotham. When the Joker and Harley Quinn hear word of the Bird’s new girlfriend, they hatch a vicious plan to finally rid themselves of Batman.

A Joker Story - "Definitive Therapy" was commissioned and paid for by DC Comics for an anthology called The Further Adventures of The Joker to tie in with the first Batman movie.