When the world needs a powerful witch arrested, a demon monster evicted, or a cursed truck to be towed, who do they call? The Guardians, protectors of mankind. Lead by world renowned spy, Kim Possible, she commands a team of super-powered teens, such as Ben Tennyson, who can transform into aliens, Danny Fenton, who can transform into a ghost, Zak Saturday, who can take control of cryptids, Jenny Wakeman, a robotic super-solider, and Elyon Brown, a stranded queen from another dimension. Together, they will rid the world of evil, protect the innocent, and solve the mystery of the Plague Doctors, the assaulters who stole Elyon's powers.