It is Derek's first day at college and he finds out his roommate is not his friend Mark but is a girl named Meredith Grey. After talking and getting to know each other he realises that he has a crush on his roommate but does she feel the same way.
The other students in their hall at Seattle prep will become closer than they thought.......
After finding out that Lydia is his daughter, Jackson struggles to balance being a dad and being a doctor, all while trying to rekindle his relationship with April.
Sequel to On The Radio