In a world where Quirks shape society, one boy was born without one... but gained something far more extraordinary...! Years ago, world-renowned scientist Inko Midoriya vanished under mysterious circumstances, leaving behind her son, Izuku, in the care of Dr. Otto Octavius. Raised in the heart of Horizon Labs and surrounded by some of the brightest minds in the world, David Shield, Curt Connors, and Otto himself; Izuku dreamed of becoming a hero... even without a Quirk! That dream seemed impossible until the bite of a genetically engineered spider changed everything. Now, armed with incredible spider-like abilities and a strong moral compass, Izuku swings through the shadows of Musutafu as the mysterious vigilante known only as Spider-Man. But with great power comes even greater responsibility, especially when sinister forces begin to rise... Can a Quirkless boy with spider powers rise to become the symbol the world needs or will the web of fate unravel?

This takes place in a universe where DC's America and My Hero Academia's Japan exist together. After being told by literally everyone in the quirk filled society of Japan that he can't be a hero, even by his idol All Might, Izuku winds up proving them wrong not long after. Someone from a certain team sees his heroic actions and hidden talents and gives Izuku the greatest offer of a lifetime: Meet the world's greatest superheroes. Will Izuku prove to the world's greatest defenders that he has what it takes to be everyone's hero?