Emma Rose Scamander is the adopted daughter of the infamous Newt Scamander, a magical zoologist with a crazy case full of many magical creatures. When the two go on a trip to New York City to bring release a thunderbird back to his home, a couple of the creatures accidentally get released into New York City. Now it's up to them, the Goldsteins Sisters, and a muggle named Jacob Kowalski to catch them all. But what happens when they hear news of an Obscurus in the "city that never sleeps"?