Kona is a young mermaid who has a thirst for adventure and exploring unknown areas despite the potential danger of being spotted by a human. The thrill of finding something new keeps her going and she never gives up the opportunity for an adventure. One day while exploring another shipwreck, she finds several mysterious objects and encounters the sea fairy Delphi who comes from another world called the Ocean Kingdom. Delphi tells her that the Kingdom was taken over and destroyed because a group of evil, corrupted sirens who have now turned their sights on conquering the human world as well. Delphi tells Kona that she is on a quest given to her by the prince of the Ocean Kingdom to find the legendary warriors known as the Precure as they are the only ones said to have the necessary power to not only protect the human world but to revive the Ocean Kingdom as well. Kona and three humans become the legendary warriors and join Delphi on her quest while discovering themselves and overcoming their own personal issues along the way.

Ten years ago in 20XX, the famous game developer Dr. Nebula had plans to release a new revolutionary Cyberworld-exclusive game called "PrettyCure.exe" which initially personalizes the player's experience for example transforming and have the upmost fun. However the mad scientist Dr. Cerius has corrupted the code for the game and used it to create the mysterious Terrorbytes! Nebula and many other world wide companies retaliated by creating the Pretty Cure Numbers, android heroines who fight with magic and technology to save their designated area. Today, Aosemura "Nikko" Nikou is a 14 year old who lives in the advanced Mitsukaido, also why she's very good in martial arts. But her life turns another direction when the sole city protector Cure Pyro unable to fight any longer. Nikou must join forces with her Navigator Electro in order to transform into Cure Glitch. Together with Cure Pyro and Cure Tunes, a new team of heroes arise. Drive Pretty Cure!