Issei was Hated by The Entire Supernatural for the actions he did not perform, he was humiliated and ignored for his deeds, being seen a Monster and Villain to The Supernatural Eyes, His brother Dai took the credit of defeating 666 Trihexa since it was Issei who defeated him, he is seen as a Hero and Savior of The World as Issei was in The Hospital, when he learned about what happened he snapped, he fight through the Hospital to Escape and the only ones who can help him are his enemies.