now in a normal life, Nathan and Ella Drake put their treasure hunting, thieving selves in the past, however, when Nate's brother, Samuel Drake returns, Nate and Ella are thrown back into the business to save Sam by finding Libertalia and it's treasure, unfortunately, an old friend of theirs, Rafe Adler, is still on the hunt for the treasure and won't let anyone get in his way.

a year after Shambhala, Nathan and Ella Drake go out in search of the fabled "Atlantis of the Sands", however, it won't be easy for the two, an old enemy, Katherine Marlow, her henchman, Talbot, and her best friend, Anne Davis, are also on the search and one is out for personal revenge, causing the search to be more of a struggle for survival once again.

two years after the El Dorado adventure, Nathan Drake is betrayed by friend, Harry Flynn and sent off to Prison, after his release by the help of Victor Sullivan, Ella Davis, and Chloe Frazer, they learn that Harry is working for a madman by the name of, Zoran Lazarevic, who is looking for both Shambhala and the Chintamani Stone, Nate, Ella, Chloe, and Elena must race the madman and find the entrance before he does

After uncovering the lost coffin of Sir Francis Drake, friends Nathan Drake and Ella Davis seek out the fabled El Dorado with the help of journalist Elena Fisher and their mentor and friend, Victor Sullivan, when a mercenary group led by Gabriel Roman enters the picture, it becomes a race to find El Dorado and the treasures with it.