Just after they witness Earth's destruction, Leonardo, Raphael, Donatello, Michelangelo, April O'Neil, and Casey Jones join forces with their new ally, Professor Fugitoid, in a desperate, long journey to prevent it from happening after jumping back in time. Which is easier said than done when they experience an unforeseen transportation to a whole new, bizarre world being protected by individuals who are more than they appear at first glance.

When a mysterious mystical anomaly traps Leonardo in another universe as a winged horse, he struggles with his new identity. Balancing his strict bushido code with equine survival instincts, he forms an alliance with one of the herd's outcast to face many enemies that threatens both their lives all because of a prophecy that has shifted from his presence and left nearly everyone in a constant state of hostility and fear for the future of Anok.

A full year after the war for Cybertron, which is thriving thanks to Optimus Prime's sacrifice, Knockout, the former chief medical officer of the Decepticons, is struggling to fit in and be useful while the dark cloud of Starscream's reign is approaching. To further complicate things, some faces, both new and old, manage to slither their way into what is occurring, testing Knockout's will to redeem himself for the things he's guilty of.

Defeated and getting sent off from existence, presumed to be dead by Sonic and his team, Infinite is brought to a new dimension. A dimension that might not be able to handle his very presence and is forced to tread carefully if it doesn't want him to reset it.

Donatello accidentally causes a unique occurrence that turns two of his brothers into cats, and the transformed brothers must learn to adapt to their new bodies as well as all the things that come with feline biology.

Leonardo, a once-proud and confident mutant turtle, is subjected to an unexpected mutation and struggles to find himself as he comes to terms with the heavy fog of his new form. Even when his new and old instincts constantly clash.

Stuck in a primitive world and in an unfamiliar body, Megatron, the former leader of the Decepticons, adapts to his changes out of necessity and patiently plans how he will conquer the four Clans of the forest. Along the way, he might run into some familiar faces.

Leonardo, Raphael, Donatello, and Michelangelo unintentionally get caught up in a war between two factions of transforming robotic organisms and are put under Optimus Prime's protection. But what they won't expect is that their presence has already caught Megatron's attention.