Useless Bones combines multiple genres like; comedy, Isekai, and Revenge into one. The story takes place in a future where Isekai stories are common knowledge to everyone. But when they get transported to another world, everyone is blinded by the fantasy of it. Blinded by becoming a "Hero" of a new world, they get corrupted and lose who they once were. It's up to Zeake to attempt to free them or leave them.

The story revolves around Ryan and his imaginary isekai romance story trough the mario universe. He meets diverse of people including Waluigi, which he ends up falling in love with. The story is purely a joke and a crack