When a wave of Antimatter begins to spread across the entire Multiverse, its Greatest Heroes assemble to fight it and save everything. But the Monitor's Prophecy ways heavily on the Heroes, especially those who are fated to die.

The Teen Wolf universe (S5 E20 AU) crosses over with The Vampire Diaries universe (S2 E22 AU) when True Alpha Scott McCall kills Sebastien Valet, unknowingly evoking an ancient rite of passage.