A year after rescuing his parents from the clutches of Amanda Waller and The Suicide Squad, Ben Tennyson once again finds himself running back to where he was running away from. It becomes more unavoidable having discovered the secret alliance of some forces on Earth with outer worldly connections. They are elusive, but thorough in their attempts of acquiring a rare mineral that is coincidentally - it seems - abundant on Earth. Such attempts however, would lead to the highly probable deaths of tens to hundreds of million people. Ben Tennyson, his comrades and fellow heroic allies from the Justice League will have to figure out a way to stop it all and prevent such grave consequences.

After the aftermath of his last great battle- he had finally gotten rid of Vilgax, his greatest ever enemy for good, but at what cost? Since that day, Ben 10, the infamous defender of Earth had gone under the radar. He didn't fight aliens anymore, he didn't use the Omnitrix anymore. There was no joy left for him- not after everything that happened. There was nothing. Even after 4 years away from Earth, he found himself wondering- What left? What could life offer him now as he returned home?