Ang Noli Me Tángere ay isang nobelang isinulat ni Jose Rizal, at inilathala noong 1887, sa Europa. Hango sa Latin ang pamagat nito na may kahulugang "huwag mo akong salingin (o hawakan)". Sinipi ito mula sa San Juan 20:17 kung saan sinabi ni Hesus kay Maria Magdalena na "Huwag mo akong salingin sapagkat hindi pa ako nakaaakyat sa aking ama.". Mas madalas itong tinatawag na Noli; at ang salin nito sa Ingles ay Social Cancer. Sinundan ito ng El Filibusterismo.) Noli Me Tángere (Latin for Don't Touch Me ) is a novel written by José Rizal, one of the national heroes of the Philippines, during the colonization of the country by Spain to describe perceived inequities of the Spanish Catholic priests and the ruling government. Originally written in Spanish, the book is more commonly published and read in the Philippines in either Tagalog or English. Together with its sequel, El Filibusterismo, the reading of Noli is obligatory for high school students throughout the country.

From the renowned Filipino reformist and national hero Dr. Jose Rizal comes a classic piece of literature that served as the spark for the nation's revolution and the eye-opener regarding the disease that has been festering within the Philippine society during the Spanish era. After seven years of studying in Europe, a wealthy young gentleman by the name of Juan Crisostomo Ibarra returns to the Philippines, filled with hope and inspired by dreams for the betterment of the country. Armed with sheer determination and a firm and positive outlook on things, he commits himself to continuing his father's philanthropical work, pioneering projects aiming at the development of the people's welfare by providing means to education and livelihood. While there are people who are avid supporters of the young man's cause, there exists in the shadows an entity as dark and malicious as the abyss it came from, shrouded deeply by lies and deceit and the hypocrisy that spawned it, hell-bent on destroying everything that stood in its path...