What happens when a 'Nobody' accidentally kisses the high school queen? A world of chaos opens, that's what! Kira Aniston has it all-wealth, beauty, and an ego the size of her family's empire. She's untouchable, unstoppable... until a humiliating accident threatens her reign. In front of the entire school, she finds herself locked in an accidental kiss with Aksel, the awkward new transfer student who couldn't be further from her type. Furious and humiliated, Kira is determined to make his life a living nightmare. And what happens when you realize that your long time crush isn't what you thought it would be? You'll be disappointed, yes! Aksel, a new transfer student, has admired Kira from afar for as long as he can remember, but after their awkward encounter, the reality of who she is doesn't quite match the fantasy he built in his head. As Kira wages her personal vendetta against him, he starts seeing through the cracks in her perfect image. What happens when Kira learns they will be living under the same roof? Will she learn to compromise or will she keep being at his throat?

Ang Mutya ng Section E ay sumusunod sa paglalakbay ni Mutya, isang matalino at masigasig na kabataang babae mula sa Section E, isang klase na madalas hindi binibigyang pansin ng iba. Sa kabila ng mga pagsubok at mga inaasahang inilalagay sa kanya, ipinapakita ni Mutya ang kanyang katalinuhan, katatagan, at determinasyon upang magtagumpay hindi lamang sa akademiko kundi pati na rin sa kanyang personal na paglago at mga relasyon. Habang tinatahak niya ang buhay ng isang mag-aaral sa hayskul, nakakaranas siya ng mga isyu tulad ng pagkakaibigan, problema sa pamilya, pagdududa sa sarili, unang pag-ibig, at ang tensyon ng pagiging totoo sa sarili at pagsunod sa mga inaasahan ng iba.