Rowan Platts is addicted to success. When she's presented with the chance to work on a top secret project fronted by her idol, renowned virologist Dr. Margot Miller, Rowan signs her life away without second thought. The realization she's gotten in over her head comes only after the subject of their study is revealed: a boy with a bad attitude and an uninhibited taste for human blood. He's a medical anomaly. Having the ability to crush metal with his bare hands and hear a heartbeat from across the room, it would make Rowan's career if she was the one to discover what made him so unusual. Easier said than done, with a subject who prefers snapping necks over answering questions.

Avery Quinton is a rebel. So when she gets expelled from her fourth boarding school her parents decide it's time to fly her home. Trent Ashton isn't normal. He's rude, conceited and selfish. And according to Avery, he has one too many secrets. They both get on a plane to Manhattan, only, the flight never makes it. Now they're stuck on an island together. They're going to wish they never got on Flight 21.