Mark Sloan is a world class attending plastic surgeon. Wise beyond his years, he has touched millions of lives. He is alone; broken. And then he meet Lexie Grey. Lexie Grey is a surgical intern, younger sister of Meredith Grey. Just getting started in her career, she's looking for love. And then she meets the much older Mark Sloan. And sparks fly.

Calliope Torres is a world class orthopedic surgeon. Being bisexual, she never really knew where she stood. Until she met the stunning Arizona Robbins. Arizona Robbins is a new pediatric surgeon and SGH, and is incredibly talented. Struggling with her sexuality her entire life, she finally finds her missing puzzle piece: Callie. Just as they become close- a tragedy happens, testing their love and limits.