The sun falls out of the sky and onto what is now called The Dome that has encased Earth's atmosphere, shattering the sky as humans know it. A chunk of The Dome falls into the ocean, causing a dramatic sequence of earthquakes, tsunamis, and other natural disasters that have killed off most of the population, and now those remaining are getting strange feedback signals from what appears to be nowhere. Seventeen-year-old Lily and her fourteen-year-old brother Parker are some of the few who have survived. In an earthquake, a pole impaled Parker, and he is mortally wounded, and Lily doesn't know who she can trust. Or what it is that is starting to descend through the hole in the dome.

The government has decided to make new weapons using a new chemical weapon mixed with a virus to instill in humans. They decide that the most suitable hosts are teenagers and hatch a plot to take random kids from different schools whose parents either don't care, are absent, or will never even know their missing. Unknown to them is that even in a suitable host, the virus can mutate and cause the person to slowly eat the person alive from the inside out while the chemicals drive the human mind insane, causing wild and erratic actions. Each virus is mixed with a different chemical compound. Each new mix in each new host causes completely different effects in each individual. A catch no one expected was that 4 of the 150 kids they collected are all from the same school, and all are extremely talented. Each of the 150 is divided into groups of 10, each one under a general who operates their faction.