Lianne Jasmine Saludes, or her nickname Lia. She's an academic achiever na may masungit na personality na ayaw siyang istorbohin sa kanyang life goals. And there's a guy named Mark Anthony Sebastian, or his nickname Anthony na academic achiever din, joker at mahilig mang-asar sa kaniyang kaibigan. Kaya bang tiisin ni Lia ang kakulitan ni Anthony? O kaya bang tiisin ni Anthony ang pagiging mainitin ang ulo ni Lia? Magiging magkaaway pa rin sila? or dito magsisimula ang kanilang friendship?

Lia & Anthony just graduated from Junior High School at Mabini. This time, they're already in the senior high school phase. Magkaibigan na sila since grade 7, mas lalo nila madidiscover ang tunay nilang personalidad. Their friendship is still strong; however, both have deep secrets they never tell each other. The struggles, challenges, and failures they experience, especially in relationships with someone they love. In their college era, there were a lot of misunderstandings between them, which led to a serious rivalry. Matutuloy pa rin ang relationship nila as best friends? Or dito na matatapos Ang kanilang closeness?