When two women in Silver Spring, Maryland, are found dead after being missing for two days, the BAU of the FBI is called in. The letters carved into the dead women's bodies seem to hide a message, but who can decode it? Enter Dr. Spencer Reid, brilliant member of the BAU. The case gets even stranger when the members of the team start disappearing one by one . . . starting with Dr. Reid.

Six years ago, the BAU team watched their youngest member fall apart, and now as he grows secretive and distant again, they start to think the worse. Their suspicions get worse when they are called to Las Vegas to assist on a serial killer case and he closes himself off but when Dr. Spencer Reid disappears from his hotel room, the team have to work quickly to find him before they have another body on their hands.