(Sequel To Romance In A&E) Ainsley and Madi survived the crash that almost killed them. Now, things have changed. Ainsley is torn between Sam and Cal. She loves them both but finds it hard. With Cal intrested in other women, can Ainsley ever find the one guy she loves? But, will Cal change his ways and prove to Ainsley he's serious and committed or will Ainsley find love in Sam? Either way, its not going to be easy.

Lola Beauchamp is Connie's eldest daughter. She's new to the ED on a training course. Lola meets Iain and immediately, sparks fly. Connie wants the best for her daughter so its natural she won't approve but thats never stopped Lola. Lola is a livewire and does whatever she wants. Can this young promising nurse and paramedic make their relationship work or will people get in the way?

Mia Turner is the newest nurse in Holby ED. She's fresh from University. Mia meets Iain and they clash. They're both strong tempered. When Mia and Iain get trapped in a hole, they have a heart to heart. Iain admits he's still partly in love with Rita. Mia tells him she's suffered with an eating disorder and now wants to help people get better. She's also fresh from a bad relationship. Can Iain and Mia find love with their second hand heart?

Aria is the newest nurse to Holby ED. She's young, confident and cocky. Immediately, Cal decides he wants her. Things soon become complicated when Iain decides he wants her. Both men are fresh from relationships and they both want Aria. What will Aria choose? Will she choose the handsome paramedic or the womanising doctors? Either way, it won't be easy.

Ainsley left when no one was expecting it. She went to New York with the kids. But now... She's back with a surprise for one of her lovers. Returning to Cardiff won't be easy. Especially now Cal is having an affair with Alicia. It's not long until Ainsley begins to regret returning to the ED. But can she fight her feelings?

Aimee Jacobs. Nurse in ED. Expecting a baby with Dr Knight. What happens when Aimee's sister Meghan is admitted to the ED following an attack? Aimee hasn't seen her sister in over a year. Will the relationship stay the same or has it changed? Iain and Ethan both fall for Meghan but who will she choose? The paramedic or the Doctor?

Olivia Beauchamp and Amanda Collier are best friends and they work at Holby ED. Olivia falls for Dr Knight while Amanda slowly falls for new paramedic Iain Dean. Both girls know their parents won't approve but will it stop them.

Nineteen year old Mia is a relationship with Iain Dean. She thinks she loves him until one night with Cal Knight makes her question everything. When Iain meets new girl Lauren, he tries to hide what he feels for her. However, feelings get in the way and soon enough Iain and Mia question their relationship and they come to the conclusion they love others.

Brooke and Emma were the closest of sisters until Brooke left unexpectedly. Emma is with Iain and Brooke with Cal. Now, Brooke is back with a shock for her sister and Cal. She has a three year old daughter. Cal's daughter to be precise. Brooke keeps many things hidden from her family but can she rely on them when things get hard? Or will she run again?

Chloe and Emma are the new girls at Holby ED. Chloe is soon romanced by Cal Knight. Emma slowly falls for Iain but this is Holby City Hospital nothing will be easy. Chloe has things she doesn't want revealing and Emma is the quiet one. She knows she won't be able to fall in love but that doesnt stop Iain from trying to win her around. Cal charms Chloe into his arms but will it be a romance that lasts?