The story of Lee Everett, a convicted criminal, who has been given a second chance at life in a world devastated by the undead. With corpses returning to life and survivors stopping at nothing to maintain their own safety, protecting a little girl named Clementine may offer him redemption in a world gone to hell.

Set right after the events of Lost Hope, Descent follows Bel's desire for revenge that pits him against foes that force him to make radical decisions. Rex, conflicted by the discovery of his past, struggles to come to terms with his demons while fighting to stop the plans of his other self. And finally Kat... a girl woken from a lab in Texas fights off demons of her own, while piecing together pieces of her past with help from the werewolves. These three characters, by choice or fate, spiral deeper into a plot connived by unknown forces they have no power over.

We may choose to forget our past, but no matter how far we run, they'll always catch up to us. To outcast Shinigami, Terry Bond (Rex), his past catches up to him in New York when he chooses to save a classmate from danger. His actions herald a chain of events that lead him to a past he buried... and should have stayed buried.