These are the many reasons that I believe megamind could be considered an UwU boy.

After geno starter to get better not at the hospital all the time, fresh started to feel... Off. Fresh now suffers from the parasite inside him to gain control. Like any parasite would, to kill its host. As fresh fights back in the hospital now with the courage from his friends and family. This story is based off the un-canon series "mama CQ" all art and pictures and characters used do not belong to me unless said. this is NOT canon.