There have been no communiques from Earth post Singularity. The Martian colonists wonder if the race abandoned space-time altogether. But for right now, they have bigger problems. Their sun is going supernova—well ahead of schedule. The two greatest minds of the time, one a scientist, the other a philosopher, concoct a two-pronged plan to save the human race. Frakas, the bioengineer, will continue to seed humanoid and increasingly alien life forms across the heavens using space warping ships. But higher consciousness isn’t exactly his specialty. And the one man who can be bothered to think beyond mean survival, his philosopher friend, Draxor, must be cloned before he passes. Only he can continue to uplift the ragtag worlds of hearty pioneers with little time to savor the finer things in life. Only he can ensure that, for those who choose to remain in the physical universe post Singularity, evolution will win out against the increasingly stronger pull towards barbarism. Thus is born The Hundred Year Man who reigns before passing the torch to the next clone. There is just one problem. The Hundred Year Man is just a prototype—and he’s flawed.

In the darkest corners of lower Manhattan, a battle like no other rages. The city is home to a hidden group of survivors of the nanite plague, and a brother and sister born to defend their race. With a touch that can destroy nanites, Lanni, sister of Alex, is their last chance. Can she save her brother? Can she protect mankind's only hope? Or will she be responsible for the destruction of the last humans on earth? It's going to be another long day....... Killing Tiffany Hudson was just the beginning, but there is so much more to the story surrounding Diane and Crane's meeting in post-apocalyptic Manhattan. Children of the Plague tells the story of the survivors in the city, including Diane and some new characters you'll want to meet.