Meredith was a 3rd grade teacher in Seattle and Derek was a mechanic. Over a spilled cup of coffee on a Thursday morning the two fall in love, but there's something that puts a strain on their relationship. Will the two push it aside to be together? Or will they forget about each other and move on?

Meredith Grey has a very overprotective brother named Mark. But what happens when Meredith sleeps with Derek Shepherd, Mark's best friend?

Alex World turns upside-down when Izzie returns to Seattle. But there's one thing she should have told him before she left. 5 Years later it might be to late to clear things up. Lilly is an unforeseen surprise to everyone and Alex has to adjust to a completely different life, because not only does he need to cope with becoming the dad of a five year old, but also deal with a surprise by Jo.