After failing to kill stubborn survivor Laurie and taking a bullet or six from former psychiatrist Dr. Sam Loomis, Michael Myers has followed Laurie to the Haddonfield Memorial Hospital, where she's been admitted for Myers' attempt on her life. The institution proves to be particularly suited to serial killers, however, as Myers cuts, stabs and slashes his way through hospital staff to reach his favorite victim.

On a cold Halloween night in 1963, six year old Michael Myers brutally murdered his 17-year-old sister, Judith. He was sentenced and locked away for 15 years. But on October 30, 1978, while being transferred for a court date, a 21-year-old Michael Myers steals a car and escapes Smith's Grove. He returns to his quiet hometown of Haddonfield, Illinois, where he looks for his next victims.