After the death of Ryan Kerrigan, Amelia Shepherd decided to get sober, and eventually found out she was pregnant with a baby girl. After getting sober she moved back to Seattle, Washington with her daughter Charlotte. Flash forward 15 years later, and Amelia falls in love with the cute pediatric attending at work, but Amelia isn't sure if shes comfortable with her sexuality. Her daughter doesn't know her crush. Could she keep it a secret? Would Charlotte accept her mother?

Alex and Jo finally had their first baby girl, like Jo always dreamed of. She never thought the day would come to start her intern days at Grey-Sloan Hospital, especially surrounded by friends and family. What would happen though when she has drunk nights at Emerald City Bar?