Earth was once a place where humans thrived and lived out their daily lives, however 1000 years have long passed since the planet Earth was abandoned and humans now reside in space and on other newly discovered planets with new species. One day, a young girl explores the ancient ruins we once called earth and finds the broken down body of a long lost hero. As gratitude to her reviving him and having a common goal in mind, the two friends go out on an adventure searching for the ancient mother board as well as looking for a way to return the memories of Astro.

Set in futuristic Metro City, Astro Boy follows the story of a young robot who was created by a brilliant scientist in the image of the son he has lost.