Weeks have past since Serena began her transformation, her cocoon is smaller and she's more dangerous than ever when she rips her way out of it. Angered by her mental battle with the Red Queen of the Xenomorph pure-bloods, she's out for carnage. Blood-lust, fury, death and an enemy no one saw coming, this is a new threat that will shake the very foundations of Lv-426.

There has been a 4 different types of xenomorphs on earth that have created hives causing a outbreak as well as two predator clans at war with each other dropping down into the planet. While this happens a ship arrives on the planet with multiple strains of aliens mainly being the neomorph, protomorph, and the Ultramorph. The outcome can't be predicted in this war.