Imai Harumi is a retired child idol and is now spending her retirement at Amber Academy. However, even after retiring she still gets fans coming at her in every direction. One day to get away from her fans she meets Citrine a fairy whose been banished from Crystalina for releasing the Prism Gems! As punishment he has to set out to find the Pretty Cure before the gems get taken by Prince Ash and his knights. Luckily, Harumi is one of the Pretty Cure! And she's not alone together with Chuya and Kiaria they become Pika Pika Pretty Cure Jewels!

The story takes place a few years after the events of Suite Pretty Cure. The series takes place a few years after the original series in the sistering town, Aria Town when the main characters: Elise and Yuu alongside their best friend Ayame will become the legendary warriors known as Melodic Pretty Cure; consisting of Cures Conch, Lyre and Ballad who must alongside their mascot Song stop the evil woman known as Hush who is slowly erasing all music and sound from not only earth but also Major Land. And the only solution or hope of saving it, being to collect all 50 of the music crystals. But how can they when two other Cures appear? Will they fight together? Or will they fight against each other?