Mula sa probinsya, lumuwas si Clarisse sa Maynila para mag-college. Then, one day, she met Jeremy. 'Yon nga lang, he had a bad impression on her. At nang akala n'ya'y malabo na silang magkitang muli, she found out that they're classmates! From strangers, they became enemies to friends. Hanggang magkagustuhan sila sa isa't isa't ligawan ni Jeremy si Clarisse. Kulang na lang ay maging sila. But, one day, Clarisse married another man. Jeremy was left devastated after that. Six years passed. May kani-kaniyang buhay na sila. Clarisse already has a son. Jeremy is about to marry his girlfriend who took care of him during his downtimes. Until, somewhere down the road, their paths crossed once more and old feelings were rekindled. Hahayaan ba nilang puso na lang ang magpasya? O dadayain na lang nila 'to para sa ikatatahimik ng lahat? Aminin kaya nilang mahal pa rin nila ang isa't isa? (Formerly "Ikaw Ang Una't Huling Mamahalin".)