A year after Annie's capture, she awakens, but this sets in motion a series of events no one knew would happen. The Titan Shifters aren't done with Humanity, and with Annie free from her Crystal, they will stop at nothing to get her back and continue with their plan. Now Annie lies on the balance between her old life and a new one. Bad and good, and the only thing making her hesitate is a certain silver-eyed girl.

En su afán por detener a Jinx de volar todo el museo de la ciudad, Vi y Caitlyn despiertan el antiguo poder de un despiadado aparato Hextech que tomara a las tres por sorpresa y cambiara el rumbo de sus vidas, acabando con la de una de ellas para siempre.