After four years since their disappearance, The Powerpuff girls Z realize that their new classmates are nothing more, nothing less than the Rowdyruff boys Z! Nevertheless, they're not what they expected. The boys don't seem to remember them and act like normal boys! What's behind this mystery? Are the boys just playing fool and planning to do something bad? And if they're telling the truth, what happened to them?

After having their hearts broken by the RowdyRuffs' disappearance, how will the girls handle it when the boys come back 5 years later?

The PowerPuff Girls were the undefeated heroes of the City of Townsville, the sisters had many foes and challenges that they faced together- though they were very young when they started fighting crime. And then the heroes disappeared. And the villains were free to do as they pleased. Though the RowdyRuff Boys never did find out what had happened to their greatest rivals...

Blossom, Bubbles, and Buttercup transfer to Uranium High School. Everything starts to fall apart when they fall for Brick, Boomer, and Butch, or should I say the vampires.

The PowerPuff Girls have had it with the RowdyRuff Boys. The girls are now teenagers, the RowdyRuffs dated them for awhile. But then they disappeared, never wrote, called, or emailed the girls. The Girls only discovered they were still alive when they see them in magazines as a famous band. The girls hate them now, for forgetting them so easily and leaving them. But when the boys show back up, what will the girls do?