FBI agent Grace Ashcroft investigates a series of murders among survivors, teaming up with plagued Leon and (y/n) Kennedy to find a cure for "Raccoon City Syndrome" and uncover the truth behind "Elpis," a secret, atoning project by Umbrella's founder.

Leon, (y/n), Chris, Jill, Claire, and Rebecca investigate a T-virus outbreak in San Francisco that leads to a new threat on Alcatraz Island.

Chris Redfield enlists the help of Leon and (y/n) Kennedy and Rebecca Chambers to stop a death merchant from spreading a deadly virus in New York.

It has been fifteen years since the Raccoon City incident and the President of the United States has decided to reveal the truth behind what took place in the belief that it will curb the current resurgence in bioterrorist activity. Due to be by the President's side is his personal friend and Raccoon City survivor, Leon S. Kennedy, but when the venue suffers a bioterrorist attack, Leon is forced to face a President transformed beyond recognition and make his hardest ever decision. At the same time, Bioterrorism Security Assessment Alliance member Chris Redfield arrives in China, itself under threat of a bioterrorist attack. With no country safe from these attacks and the ensuing outbreaks, the entire world's population is united by a common fear that there is no hope left.

Leon and (y/n) Kennedy investigate the use of Bio-Organic Weapons (B.O.W.s) in a European war zone, defying orders to uncover the truth behind the outbreak.

Leon S. Kennedy, (y/n) Valentine and Claire Redfield must battle a rogue warrior seeking revenge after unleashing the deadly G-Virus, whilst a mutated monster goes on a rampage.

Leon S. Kennedy and (y/n) Valentine investigate a hacking incident that leads to a zombie attack in the Executive Mansion which then leads to a military cover-up in Penamstan. All the while, (y/n) deals with the recent loss of her older sister, Jill Valentine.

Six years after Racoon City, U.S. government agents Leon S. Kennedy and (y/n) Valentine are sent to a remote Spanish village to rescue the President's kidnapped daughter, Ashley Graham. There, they encounter a mysterious cult and its mind-controlling parasitic Los Plagas, battling increasingly hostile villagers and other grotesque enemies while uncovering the dark truth behind their beliefs and discovering a deeper connection to their own trauma from the Raccoon City incident.

Rookie cop, Leon S. Kennedy, and college student Claire Redfield arrive in Raccoon City amidst a zombie outbreak caused by the T-virus. They, along with the help of officer (y/n) Valentine (sister to Jill Valentine) navigate the overrun city, seeking to escape while uncovering the truth behind the Umbrella Corporation's bioweapon experiments, including the G-virus, and encountering monstrous creatures like Mr. X and William Birkin.