After four years since their disappearance, The Powerpuff girls Z realize that their new classmates are nothing more, nothing less than the Rowdyruff boys Z! Nevertheless, they're not what they expected. The boys don't seem to remember them and act like normal boys! What's behind this mystery? Are the boys just playing fool and planning to do something bad? And if they're telling the truth, what happened to them?

The PowerPuff Girls have had it with the RowdyRuff Boys. The girls are now teenagers, the RowdyRuffs dated them for awhile. But then they disappeared, never wrote, called, or emailed the girls. The Girls only discovered they were still alive when they see them in magazines as a famous band. The girls hate them now, for forgetting them so easily and leaving them. But when the boys show back up, what will the girls do?