Thanks to the efforts of the future foundation and the survivors of the killing school life, Junko Enoshima's despair has greatly weakened. But one last thing stands in the way of true hope... The ultimate despair. AKA, Hope's Peak Academy's 77th class. A solution to that issue has been put into motion, but... what will you do when somethings don't go according to plan?

You have been accepted into Hope's Peak Academy as the Ultimate Psychologist, but when you meet a certain despair obsessed girl and become trapped in a game where the only way to win is to kill one of your peers and get away with it, will you do to whatever it takes to survive?