A year after the Baker House Incident, a bioweapon codenamed Dahlia appears in England. Tasked with terminating the bioweapon, Céline Durant, a trained solider employed with the Connections infiltrates the BSAA and is teamed up with Chris Redfield to combat the final known strain of the Mold. What lies in store for her is more than she is prepared to handle.

As Chris notices that something is wrong with Mia, he has no choice but to take action. Together with a unit of his best soldiers, he ventures out to do what he has to do. He needs mother Miranda dead. You're his best companion from the past but the two of you have unsolved issues. It gets worse as soon as you get closer again.