The PowerPuff Girls have had it with the RowdyRuff Boys. The girls are now teenagers, the RowdyRuffs dated them for awhile. But then they disappeared, never wrote, called, or emailed the girls. The Girls only discovered they were still alive when they see them in magazines as a famous band. The girls hate them now, for forgetting them so easily and leaving them. But when the boys show back up, what will the girls do?

Humans and Vampires have been at war for years, constant bloodshed and no resolving... well not until the king of humanity sends his 3 daughters blossom, Bubbles, and buttercup over to the Monsters school in hoping to start a resolution. It will be hard considering dealing with the Vampires/ other monsters who don't want them there, including the Vampire Kings sons. But will bickering and hatred turn into love and happiness? And will the girls finally fit in considering there secret?