One disappearance after another. Hogwarts' Magical Creatures Reserve is facing a crisis. Headmaster has no choice but to ask Newt Scamander, former student of Hogwarts, world-wide known Magizoologist, to postpone his research and help with the investigation. At the same time, Isabella Peterson is trying to fit in the wizarding world, hoping she would finally settle down as an assistant for the Care of Magical Creatures. Relationship with beasts is becoming tense. Little do they know, that there are much darker secrets behind the missing creatures.