28 years after the Millennium incident Isabeau Hellsing the granddaughter of Richard Hellsing has been taken in by Integra Hellsing after the death of her father. However the Hellsing family isn't the only blood line that corses through her blood. Her deceased mother is a decedent from Quincy Harker, Mina Harkers son. 2 years after Isabeau's arrival a certain vampire returns.