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In the underbelly of New York City, the mutants are no longer safe.
When the turtles discover that a secret federal facility has been experimenting on innocent people, their world is thrown into chaos. Survivors like Nora, Judas, and Arlo escape into the city, carrying the scars of their captivity-and painting targets on the backs of every mutant still free.
Now, hunted by the Foot Clan and TCRI, the turtles and their allies must protect those who can't protect themselves. But trust runs thin, memories are fractured, and danger is everywhere.
With old friends like April O'Neil, Casey Jones, and Vern, and new allies in Jennika's crew and the police, and hunted mutants looking to them for safety, they're faced with an impossible truth:
There's nowhere left to hide.