Milo is a struggling singer trying to break through in the industry, taking up a job at a local cafe to pay for his life in the big city, but his life takes a turn on the first day...
Gru and his family takes a vacation to Brooklyn. However, the Despicable Me villains escape AVL and team up with Bowser in order to defeat Gru and his family. This is set after Despicable Me 4.