A few months after the events with the Yokai (Robert Callaghan), and the other chaos, Hiro Hamada and his friend group, Go Go Tamango, Wasabi, Honey Lemon and Fred, are back to their normal lives, and settle in. Hiro also to enrolled into the San Fransokyo Institute of Technology (SFIT). But behind their "normal lives" they have their secret identities, and use their spare time to fight the crime that happens in their small city, San Fransokyo. But one day, they come to a different mission. It's about locating a specific missing girl. Which the youngest member of the group takes an interest in, later on.