Kamen Rider Chronicle has ended. Dan Masamune has been defeated my Hojo Emu. The world has become peaceful again. Or so we thought. In the year 2018, a new form of Bugster virus has spreaded throughout New York. The virus is called the "Neo-Bugster virus." The virus is so strong, that Emu and the others aren't strong enough to fight off this virus. Now, the world is relying on new gamers to cure the Neo-Bugster virus. These gamers are called "Neo-Gamers." These Neo-Gamers goes by the names of Basara Hatake known as Kamen Rider Ex-Aid, Zachary King known as Kamen Rider Brave, Roe Walsh known as Kamen Rider Snipe, and Nick Kujo known as Kamen Rider Lazer. Can these four gamers save the world and end the Neo-Bugster virus? Or, will the world end up like Zero Day all over again?